Structure of PDB 8ffm Chain D Binding Site BS01

Receptor Information
>8ffm Chain D (length=623) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPPPMESPFQREDRNPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYL
TDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQ
CTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTC
FYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMI
ADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEG
KIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSV
LEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFI
FTVVAYHQPSLFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISF
MDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTR
GFQHTGIYSVMIQVILRDLLRFLLVYLVFLFGFAVALVSLSREARPYRSI
LDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIA
LMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGT
RPDERWCFRVEEVNWAAWEKTLP
Ligand information
Ligand IDFZ4
InChIInChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
OpenEye OEToolkits 2.0.6		B(c1ccccc1)(c2ccccc2)OCCN
CACTVS 3.385NCCOB(c1ccccc1)c2ccccc2
FormulaC14 H16 B N O
Name2-aminoethyl diphenylborinate
ChEMBLCHEMBL169233
DrugBank
ZINCZINC000169743034
PDB chain8ffm Chain D Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ffm Molecular details of ruthenium red pore block in TRPV channels.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H521 T522 Y525
Binding residue
(residue number reindexed from 1)		H454 T455 Y458
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0009266 response to temperature stimulus
GO:0045773 positive regulation of axon extension
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0042470 melanosome
GO:0044295 axonal growth cone
GO:0044297 cell body

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ffm, PDBe:8ffm, PDBj:8ffm
PDBsum8ffm
PubMed38225355
UniProtQ9WUD2|TRPV2_RAT Transient receptor potential cation channel subfamily V member 2 (Gene Name=Trpv2)

[Back to BioLiP]