Structure of PDB 8e23 Chain D Binding Site BS01

Receptor Information
>8e23 Chain D (length=603) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRKTGFPIKGCD
DTLVVGLAVCWGGRDAYYFSLQKESLDPSLTLKDRMWYLQSCLRKEKECS
VVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTS
FLPHELPLLEGMEIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQ
KENLQDVFRKVEMPSQYCLALLELNGIGECESQKHIMQAKLDAIETQAYQ
LAHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHPLPGLILEWR
RITNAITKVVFPLQREKCLNPFLMERIYPVSQSHTATGRITFTEPNIQNV
PRDFEIISMRHAFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADV
FRSIEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAA
CYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
KAHAERQAINTIVQGSAADIVKIATVNIQKQLETTFKSHGHREGCPIRFI
LQLHDELLYEVAEEDVVQQIVKNEMESAVKLSVKLKVKVKIGASWGELKD
FDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e23 Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		T2237 T2245 N2248 G2388 M2393 S2397 R2448 N2457 Y2459 A2462 H2463 R2466 Q2467 N2470 Q2474
Binding residue
(residue number reindexed from 1)		T335 T343 N346 G428 M433 S437 R488 N497 Y499 A502 H503 R506 Q507 N510 Q514
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8e23, PDBe:8e23, PDBj:8e23
PDBsum8e23
PubMed36126059
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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