Structure of PDB 8ddx Chain D Binding Site BS01

Receptor Information

>8ddx Chain D (length=992) Species: 10090 (Mus musculus)

ISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQ
LELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTG
VIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRI
GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGH
KYSEVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDL
AILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAM
LDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR
DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPK
RPKALKLLGMEDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHG
EEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD
QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTD
MWMGRLRMRKNSGLKVILGILLPPSILSLEFKNGRKIYEFYNAPIVKFWF
YTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSE
PGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCV
NIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVA
RQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCQLPPCKTGAW
IVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMT
FHERPVLPPPLIIFSHMTMIFQHVCRDYGLKLFITDDELKKVHDFEEQCI
EEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHS

Ligand information

>8ddx Chain H (length=17) Species: 10090 (Mus musculus)

AAAAAAAAAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ddx Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): H132 T133 Q134 L135 S136 T138 S161 G300
• Binding residue (residue number reindexed from 1): H4 T5 Q6 L7 S8 T10 S33 G172

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0051262 protein tetramerization
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8ddx, PDBe:8ddx, PDBj:8ddx
• PDBsum: 8ddx
• PubMed: 36283409
• UniProt: Q5F4S7