Structure of PDB 8ddw Chain D Binding Site BS01

Receptor Information

>8ddw Chain D (length=719) Species: 10090 (Mus musculus)

ISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQ
LELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTG
VIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRI
GQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGH
KYSEVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDL
AILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAM
LDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVR
DVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPK
RPKALKLLGMEDDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGE
EAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQ
SYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDM
NKYLGPYVMMIGKMMIDNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF
HERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTS
ERVENMSMRLEEVNEREHS

Ligand information

>8ddw Chain H (length=17) Species: 10090 (Mus musculus)

AAAAAAAAAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ddw Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
• Resolution: 4.7 Å
• Binding residue (original residue number in PDB): I129 T133 Q134 L135 S136 P137 T138 R159 D298 G300
• Binding residue (residue number reindexed from 1): I1 T5 Q6 L7 S8 P9 T10 R31 D170 G172

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0051262 protein tetramerization
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8ddw, PDBe:8ddw, PDBj:8ddw
• PDBsum: 8ddw
• PubMed: 36283409
• UniProt: Q5F4S7