Structure of PDB 8d0k Chain D Binding Site BS01

Receptor Information

>8d0k Chain D (length=419) Species: 9606 (Homo sapiens)

ETFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKD
DIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQA
QEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFG
FKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKK
VHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETI
HDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQYC
FPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTIS
FICRELDAISTNEEEKEENEAESDVKHRTRDYKKTSLAPYVKVFEHFLEN
LDKSRKGELLKKSDLQKDF

Ligand information

>8d0k Chain H (length=20)

tagggttagggttagggtta

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d0k Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
• Resolution: 4.27 Å
• Binding residue (original residue number in PDB): I53 Y54 R56
• Binding residue (residue number reindexed from 1): I52 Y53 R55

Enzymatic activity

• Enzyme Commision number: 2.7.7.102: DNA primase AEP.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003896 DNA primase activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0016779 nucleotidyltransferase activity
• GO:0032553 ribonucleotide binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006269 DNA replication, synthesis of primer
• GO:0006270 DNA replication initiation

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex
• GO:0005654 nucleoplasm
• GO:0005658 alpha DNA polymerase:primase complex
• GO:0016020 membrane
• GO:1990077 primosome complex

External links

• PDB: RCSB:8d0k, PDBe:8d0k, PDBj:8d0k
• PDBsum: 8d0k
• PubMed: 35830881
• UniProt: P49642|PRI1_HUMAN DNA primase small subunit (Gene Name=PRIM1)