Structure of PDB 8cpl Chain D Binding Site BS01

Receptor Information
>8cpl Chain D (length=456) Species: 1280,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKSVT
AGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQ
NQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAAL
KLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFR
HVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAVR
KLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMP
IGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQ
AEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEM
FRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKALAAMRVSVEQ
QNAFYE
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain8cpl Chain D Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8cpl Engineered imaging scaffolds for cryo-EM of small proteins of interest.
Resolution1.605 Å
Binding residue
(original residue number in PDB)		S149 G150 T151 F180 H181 G182 E238 D271 V273 Q274 K300
Binding residue
(residue number reindexed from 1)		S141 G142 T143 F172 H173 G174 E230 D263 V265 Q266 K292
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.29: diamine transaminase.
2.6.1.82: putrescine--2-oxoglutarate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0019161 diamine transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0033094 putrescine--2-oxoglutarate transaminase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0009447 putrescine catabolic process
GO:0019477 L-lysine catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cpl, PDBe:8cpl, PDBj:8cpl
PDBsum8cpl
PubMed
UniProtP38507|SPA_STAAU Immunoglobulin G-binding protein A (Gene Name=spa);
P42588|PAT_ECOLI Putrescine aminotransferase (Gene Name=patA)

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