Structure of PDB 8ch6 Chain D Binding Site BS01

Receptor Information

>8ch6 Chain D (length=89) Species: 9606 (Homo sapiens)

KHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYG
SYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNL

Ligand information

>8ch6 Chain g (length=76)

ucggccuccgaacgguaagagccuagcauguagaacugguuaugauguca
uacuuauccugucccuuuuuuuucca

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ch6 Structural basis of catalytic activation in human splicing.
• Resolution: 5.9 Å
• Binding residue (original residue number in PDB): K3 K25 Y36
• Binding residue (residue number reindexed from 1): K1 K23 Y34

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing
• GO:0045893 positive regulation of DNA-templated transcription
• GO:0048863 stem cell differentiation
• GO:1903241 U2-type prespliceosome assembly

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0005684 U2-type spliceosomal complex
• GO:0005686 U2 snRNP
• GO:0005689 U12-type spliceosomal complex
• GO:0016363 nuclear matrix
• GO:0016607 nuclear speck
• GO:0071005 U2-type precatalytic spliceosome
• GO:0071011 precatalytic spliceosome

External links

• PDB: RCSB:8ch6, PDBe:8ch6, PDBj:8ch6
• PDBsum: 8ch6
• PubMed: 37165190
• UniProt: Q7RTV0|PHF5A_HUMAN PHD finger-like domain-containing protein 5A (Gene Name=PHF5A)