Structure of PDB 8b9z Chain D Binding Site BS01

Receptor Information
>8b9z Chain D (length=430) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAKWYPDPEFMKQFSGPVMYPDEVTSLWTVPPWNSKVTPVEKSVRNLTLN
FGPQHPAAHGVLRLVLELDGETVMRADPHIGLLHRGTEKLIEYKTYTQAL
PYFDRLDYVSMMCNEQCYSLAVEKLLNIDVPLRAKYIRTLFAEITRILNH
IMAVGTHALDVGALTPFFWLFEEREKMMEFYERVSGARMHAAYIRPGGVS
LDMPLGLMDDIYEFASKFAERLDEVEDVLTTNRIWVQRTEDIGIVTAEEA
LNYGFSGVMLRGSGIKWDLRKQQPYDAYNLVNFDVPIGTKGDCYDRYLCR
VEEMRQSLRIIDQCLNQMPAGEIKTDDAKVAPPSRSEMKTSMEALIHHFK
LFTQGYQVPPGATYTAIEAPKGEFGVYLISDGSSRPYRCKIKAPGFAHLA
ALEKIGKQHMLADVVAIIGTLDVVFGEIDR
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8b9z Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8b9z Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		R143 H228
Binding residue
(residue number reindexed from 1)		R105 H190
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0048038 quinone binding
GO:0051287 NAD binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b9z, PDBe:8b9z, PDBj:8b9z
PDBsum8b9z
PubMed36622099
UniProtQ9V4E0

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