Structure of PDB 8b5l Chain D Binding Site BS01 |
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| >8b5l Chain 5 (length=3619)
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cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggccggccgugccggcgguc
ucggcggaucuuucccgcucccgggggcgggggaccgccccccggccggc
gaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccgg
cuccgggacggcugggaaggcccggcggggaagguggcccggggggacgc
cucgccggcgggcgcgaccccuccccggguguuacagccccgccccggca
gcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccg
cgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcu
ggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccg
ggggccacggcgcgucgcggcgcgcgcgagcgagcgcacggggucggcgg
cgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucu
aacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaauga
aggugaaggccggcgucgccggccgaggugggaucccgaggccuuccagu
ccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggaggug
gagcacgagcgcacguguuaggacccgaaagauggugaacuaugccuggg
cagggcgaagccagaggaaacucugguggagguccguagcgguccugacg
ugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaacc
aucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucu
cgcccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccga
aacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucg
cugguguggagccgggcguggaaugcgagugccuagugggccacuuuugg
uaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgccc
gaugccgacgcucaucagaccccagaaaagguguugguugauauagacag
caggaugguggccauggaagucggaauccgcuaaggaguguguaacaacu
caccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucggg
cccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcg
cggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaag
ccuagggcgcgggcccggguggagccgccgcaggugcagaucuugguggu
aguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguu
ccaugugaacagcaguugaacaugggucagucgguccugagagaugggcg
agcgccguuccgaagggacgggcgauggccuccguugcccucagccgauc
gaaagggagucggguucagauccccgaauccggaguggcggagaugggcg
ccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgg
gagccccggggagaguucucuuuucuuugugaagggcagggcgcccugga
auggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuc
cggcggcguccggugagcucucgcuggcccuugaaaauccgggggagagg
guguaaaucucgcgccgggccguacccauauccgcagcaggucuccaagg
ugaacagccucuggcauguuggaacaauguagguaagggaagucggcaag
ccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccga
cuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaag
caucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagu
gcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgg
gaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuag
ugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauc
cagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaag
aagacccuguugagcuugacucuagucuggcacggugaagagacaugaga
acuccgaucguuuuuucacugacccggugaggcgggggggcgagccgggc
ucucgcuucuggcgccaagcgcccggccccggggccgggcgcgacccgcu
ccggggacagugccagguggggaguuugacuggggcgguacaccugucaa
acgguaacgcagguguccuaaggcgagcucagggaggacagaaaccuccc
guggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaaua
cagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaa
gcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggcc
aagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccu
aucauugugaagcagaauucaccaagcguuggauuguucacccacuaaua
gggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccu
acugaugauguguuguugccaugguaauccugcucaguacgagaggaacc
gcagguucagacauuugguguaugugcuuggcugaggagccaauggggcg
aagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccg
cccaggcggaacgauacggcagcgccgaggagccucgguuggccucggau
agccggucccccgcgggguccggugcggagagcccuucgucccgggaaac
ggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacg
uucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggu
cgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagc
ccucgacacaaggguuugu |
.........................<<<<<<.....<......>......
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>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>...
..>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>..................................<<<<<<<<..<<<.<
<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<..
..<<<<<.<<<..<<<<<<<<..>>>>>>>>>>>>>>>>>>>>>>>>>>>
...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<
<<<<<<<.<<<<...<<..<<<.<<<<<<<......<<<<<<<<<<....
...<....>...........>>>>>>>>>>.......>>>>>>>..>>>.
........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<
<<<<<.<<<<<<..>>>>>>.<<<<<<..<<<.<<<<<<<<<<<<<<<<<
<<<<<<.<<<<....>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>
>>>>>>.>><<<<<........>>>>>....>>>>>>.....>>>.>>>>
>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<
<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<..
..>>...<<<<<.......>>>>>..<<<<<...<<<..<<<....{{.{
{.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>
>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<
..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<..
......>>>>.>>>....>>>>>>>>>...<<.......>>......>>>
>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.
.....<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<....
.....>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.
<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.
....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.
......<<<<<.....<<..........<<<.<<<<<<<<<<.......<
<<<<.<<<...<<.........>>...>>>.........<<......>>.
..>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>
>>...>>>>>>><<<<<<.<<<.......]]...........}}.}}...
..........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<
<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.
....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...
<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<.
...>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>
....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<
<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<
<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<...
..<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.....
..>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>...
.......>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<
<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<..
...<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..
>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<
<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<
<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<
<<<<.......>>>>>>........<...........<<<<<.......>
>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>
>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{.
.....[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<....<.
....>....>>>>>>>>>>...<<<<<.....<<<<..<<.<.<<<>>.>
>.>>..............<<<<<<<<<<<..>>>>>>>>>>>..>>>>..
>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...
........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>
.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>.
.>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.))
)))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<.
..<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<
..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>
>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}
.]]]]].....<<<<<<.<..<<<..<.<<<<<.................
>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>.
..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>
.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<.......
.<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....
<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>.........
.....>>>>..>>>>>>>>><<<<<.<.............>....<<.<<
<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>
>>>.>>>.>>..>>>>>.. |
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| PDB | 8b5l Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative. |
| Resolution | 2.86 Å |
Binding residue
(original residue number in PDB) | F3 V4 K5 V6 K8 K10 A11 R15 Y16 Q17 K19 R23 G26 T28 D29 Y31 R35 L36 K43 Y44 N45 K48 F113 P139 G140 Y145 L146 L150 R152 T153 F160 H175 S176 R179 R268 Q275 D278 R279 Q282 S286 R289 |
Binding residue
(residue number reindexed from 1) | F1 V2 K3 V4 K6 K8 A9 R13 Y14 Q15 K17 R21 G24 T26 D27 Y29 R33 L34 K41 Y42 N43 K46 F111 P137 G138 Y143 L144 L148 R150 T151 F158 H173 S174 R177 R266 Q273 D276 R277 Q280 S284 R287 |
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| Enzyme Commision number |
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