Structure of PDB 8b1t Chain D Binding Site BS01

Receptor Information
>8b1t Chain D (length=601) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHV
CLPLSRLENHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGD
RLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQK
VAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPT
GKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRH
HAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVE
AGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLL
QKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYI
AMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLN
ERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRG
QGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPS
QRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFS
S
Ligand information
>8b1t Chain X (length=51) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tttttttttttttctaatgcgagcactgctagcagtgctcgcattagatt
t
Receptor-Ligand Complex Structure
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PDB8b1t Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K14 T205 T239 H241 A246 Q247 P248 V304 L444 R445 N487 T537 H539 V560
Binding residue
(residue number reindexed from 1)		K13 T200 T234 H236 A241 Q242 P243 V299 L439 R440 N482 T532 H534 V555
Enzymatic activity
Enzyme Commision number 5.6.2.3: DNA 5'-3' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0008854 exodeoxyribonuclease V activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 DNA damage response
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0009338 exodeoxyribonuclease V complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b1t, PDBe:8b1t, PDBj:8b1t
PDBsum8b1t
PubMed36533901
UniProtP04993|RECD_ECOLI RecBCD enzyme subunit RecD (Gene Name=recD)

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