Structure of PDB 8acg Chain D Binding Site BS01

Receptor Information
>8acg Chain D (length=474) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSICKSPLLVSTPLGLPRCLQASNVVKRLQKLEDIASLNDGNRAAATPGY
QASVDYVKQTLQKAGYKVSVQPFPFTAYYPKGPGSLSATVPQPVTYEWEK
DFTYLSQTEAGDVTAKVVPVDLSLGAGNTSTSGCEAEDFANFPAGSIALI
QRGTCNFEQKAENAAAAGAAGVIIFNQGNTDDRKGLENVTVGESYEGGIP
VIFATYDNGVAWSQTPDLQLHLVVDVVRKKTETYNVVAETRRGNPNNVVM
VGAHLDSVFEGPGINDNGSGSAAQLEMAVLLAKALPVNKVRFAWWGAAEA
GLVGSTHYVQNLAPEEKKKIKAYLNFDMIGSPNFGNFIYDGDGSDFGLQG
PPGSAAIERLFEAYFRLRGQQSEGTEIDFRSDYAEFFNSGIAFGGLFTGA
EGLKTEEQAQKYGGTAGKAYDECYHSKCDGIANINQDALEIHSDAMAFVT
SWLSLSTKVVDDEIAAAGQKLVPR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8acg Chain D Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8acg An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		H296 D308 D369
Binding residue
(residue number reindexed from 1)		H254 D266 D327
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0015628 protein secretion by the type II secretion system
GO:0043952 protein transport by the Sec complex
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8acg, PDBe:8acg, PDBj:8acg
PDBsum8acg
PubMed37386135
UniProtQ9HZQ8|LAP_PSEAE Aminopeptidase (Gene Name=lap)

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