Structure of PDB 8a58 Chain D Binding Site BS01

Receptor Information
>8a58 Chain D (length=80) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVC
RQRFLLKNLRPNRQLANMVNNLKEISQEAR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8a58 Chain D Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8a58 Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		C31 H33 C51 C54
Binding residue
(residue number reindexed from 1)		C27 H29 C47 C50
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:8a58, PDBe:8a58, PDBj:8a58
PDBsum8a58
PubMed37061529
UniProtP19474|RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (Gene Name=TRIM21)

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