Structure of PDB 7zpl Chain D Binding Site BS01

Receptor Information
>7zpl Chain D (length=514) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKE
VNARIEPFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGI
PLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENEE
KIPRTKNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRS
LACWIQSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSH
CRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYG
FIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRT
AVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSV
KEKDLTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYAS
PQLEGFSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLL
NASWFNSFLTHALR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zpl Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		K328 G371 E372 N373 M374 A375 Y393 S395 E397 P398 H510 R512 V517 K539 R566 T567 N568 K574
Binding residue
(residue number reindexed from 1)		K126 G169 E170 N171 M172 A173 Y191 S193 E195 P196 H308 R310 V315 K337 R364 T365 N366 K372
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zpl, PDBe:7zpl, PDBj:7zpl
PDBsum7zpl
PubMed36596301
UniProtM9TI86

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