Structure of PDB 7zh4 Chain D Binding Site BS01

Receptor Information
>7zh4 Chain D (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLNNLGNTSYLNSILQVLYFCPGFKSGVKHLFNIISRKKYELICSLQSLI
ISVEQLQASFLLNPLQHDAQEVLQCILGNIQETCQLLKKGFELVEKLFQG
QLVLRTRCLECESLTERREDFQDISVPVQEDMKTLRWAISQFASVERIVG
EDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLSKINTPLLTP
LKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTYEGKWLLF
DDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7zh4 Chain D Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7zh4 Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		C440 C443 C506
Binding residue
(residue number reindexed from 1)		C108 C111 C156
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0001501 skeletal system development
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006508 proteolysis
GO:0009411 response to UV
GO:0016579 protein deubiquitination
GO:0035520 monoubiquitinated protein deubiquitination
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:1904333 positive regulation of error-prone translesion synthesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zh4, PDBe:7zh4, PDBj:7zh4
PDBsum7zh4
PubMed36170365
UniProtO94782|UBP1_HUMAN Ubiquitin carboxyl-terminal hydrolase 1 (Gene Name=USP1)

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