Structure of PDB 7z42 Chain D Binding Site BS01

Receptor Information
>7z42 Chain D (length=715) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYEQNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYL
ADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLS
NESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQT
ISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKL
TWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAK
ECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQ
KTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEM
NLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMK
YVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHL
RGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYC
RVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGD
RVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAE
SRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWL
GFEKEGSKVLESVDE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z42 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution2.418 Å
Binding residue
(original residue number in PDB)		K330 T366 G367 G369 L370 T371 P391 K392 I393 H506 R508 D512 V513 T515 V559 N560 G561
Binding residue
(residue number reindexed from 1)		K323 T359 G360 G362 L363 T364 P384 K385 I386 H499 R501 D505 V506 T508 V552 N553 G554
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z42, PDBe:7z42, PDBj:7z42
PDBsum7z42
PubMed35605026
UniProtQ5V8Z9

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