Structure of PDB 7z3n Chain D Binding Site BS01

Receptor Information
>7z3n Chain D (length=519) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APGERVVIGITFGNSNSSIAHTVDDKAEVIANEDGDRQIPTILSYVDGDE
YYGQQAKNFLVRNPKNTVAYFRDILGQDFKSVDPTHNHASAHPQEAGDNV
VFTIKDKAEEDAEPSTLTVSEIATRYLRRLVGAASEYLGKKVTSAVITIP
TNFTEKQKAALIAAAAAADLEVLQLISEPAAAVLAYDARPEATISDKIIV
VADLGGSRSDVTVLASRSGMYTILATVHDYEYHGIALDKVLIDHFSKEFL
KKNPGAKDPRENPRSLAKLRLEAESTKRALSRSTNASFSVESLIDGLDFA
STINRLRYETIARTVFEGFNRLVESAVKKAGLDPLDVDEVIMSGGTSNTP
RIAANFRYIFPESTRILAPSTDPSALNPSELQARGAALQASLIQEFETED
IEQSTHAAVTTMPHVTNAIGVVSVSEKFVPIIAPETAVPARRTVHLDAPK
EGGDVLVKVVEGSTHINVREKVWKIGSTLAEAAVRGVKKGAKVEVTINVN
TDLTVIVTAREVGVRGTLS
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7z3n Chain D Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z3n Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G21 N22 S23 N24 R80 G213 G214 R216 K285 R286 G352 G353
Binding residue
(residue number reindexed from 1)		G13 N14 S15 N16 R72 G205 G206 R208 K277 R278 G344 G345
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7z3n, PDBe:7z3n, PDBj:7z3n
PDBsum7z3n
PubMed37081320
UniProtG0RZX9

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