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Receptor Information

>7z0s Chain D (length=306) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SVLYPLIQALVLFAVAPLLSGITRVARARLHNRRGPGVLQEYRDIIKLLG
RQSVGPDASGWVFRLTPYVMVGVMLTIATALPVVTVGSPLPQLGDLITLL
YLFAIARFFFAISGLDTGSPFTAIGASREAMLGVLVEPMLLLGLWVAAQV
AGSTNISNITDTVYHWPLSQSIPLVLALCACAFATFIEMGKLPFDLAEAE
QELQEGPLSEYSGSGFGVMKWGISLKQLVVLQMFVGVFIPWGQMETFTAG
GLLLALVIAIVKLVVGVLVIALFENSMARLRLDITPRITWAGFGFAFLAF
VSLLAA

Ligand ID

DR9

InChI

InChI=1S/C40H75O10P/c1-3-5-7-9-11-13-15-17-18-20-21-23-25-27-29-31-39(43)47-35-38(36-49-51(45,46)48-34-37(42)33-41)50-40(44)32-30-28-26-24-22-19-16-14-12-10-8-6-4-2/h14,16-18,37-38,41-42H,3-13,15,19-36H2,1-2H3,(H,45,46)/b16-14-,18-17-/t37-,38-/m1/s1

InChIKey

QGIXWNRQEFVVRM-CTDKCSBDSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCC(CO)O)OC(=O)CCCCCCCC=CCCCCCC
ACDLabs 10.04	O=C(OC(COP(=O)(OCC(O)CO)O)COC(=O)CCCCCCC\C=C/CCCCCCCC)CCCCCCC\C=C/CCCCCC
OpenEye OEToolkits 1.5.0	CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](CO[P@@](=O)(O)OC[C@@H](CO)O)OC(=O)CCCCCCC\C=C/CCCCCC
CACTVS 3.341	CCCCCCCCC=CCCCCCCCC(=O)OC[CH](CO[P](O)(=O)OC[CH](O)CO)OC(=O)CCCCCCCC=CCCCCCC
CACTVS 3.341	CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](CO[P@](O)(=O)OC[C@H](O)CO)OC(=O)CCCCCCC\C=C/CCCCCC

Formula

C40 H75 O10 P

Name

1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL;
(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE

PDB chain

7z0s Chain E Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7z0s Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	F187 F235 K263 G267 F274
Binding residue (residue number reindexed from 1)	F186 F234 K262 G266 F273
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0016491	oxidoreductase activity

	Biological Process
GO:0006007	glucose catabolic process
GO:0009061	anaerobic respiration
GO:0015944	formate oxidation
GO:0019645	anaerobic electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0009326	formate dehydrogenase complex
GO:0016020	membrane

PDB	RCSB:7z0s, PDBe:7z0s, PDBj:7z0s
PDBsum	7z0s
PubMed	36104349
UniProt	P16430\|HYCD_ECOLI Formate hydrogenlyase subunit 4 (Gene Name=hycD)

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Structure of PDB 7z0s Chain D Binding Site BS01