Structure of PDB 7yxb Chain D Binding Site BS01

Receptor Information

>7yxb Chain D (length=192) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVT
ELGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTV
YPAKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRARSE

Ligand information

>7yxb Chain H (length=19) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AFAPVSKMRMATPLLMQAG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7yxb MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Resolution	2.095 Å
Binding residue (original residue number in PDB)	H13 Y30 Y37 P56 D57 W61 L67 Y78 H81 N82 V85
Binding residue (residue number reindexed from 1)	H12 Y29 Y36 P55 D56 W60 L66 Y77 H80 N81 V84

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:7yxb, PDBe:7yxb, PDBj:7yxb
PDBsum	7yxb
PubMed	37142807
UniProt	A0A1V1IGJ9

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