Structure of PDB 7yi3 Chain D Binding Site BS01

Receptor Information
>7yi3 Chain D (length=316) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TISEDSKVSVTGLPLNKGPSEKIKRESLWNDLKTFLTENMTEESNIRSTI
GWNEDFCSACNQSGSFLCCDTCPKSFHFLCLDPPIDPNNLPKGDWHCNEC
KFKIFINNSMATLKKIESNFIKQNNNVKIFAKLLFNIDSHNPKQFQLPNY
IKETFPAVKTGSRGQYSDENDKSYNPDTHIDSNSGKFLICYKCNQTRLGS
WSHPENSRLIMTCDYCQTPWHLDCVPRASFKNLGSKWKCPLHSPTKVYKK
YKVWKKQRLINKKNQLYYEPLQKIGYQNNGNIQIINQDFKITQIDENSIK
YDFFDKIYKSKMVQKR
Ligand information
>7yi3 Chain E (length=20) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NSIKYDFFDKIYKSKMVQKR
Receptor-Ligand Complex Structure
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PDB7yi3 Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		K548 F552 Y556 M560
Binding residue
(residue number reindexed from 1)		K300 F304 Y308 M312
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006368 transcription elongation by RNA polymerase II
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060195 negative regulation of antisense RNA transcription
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0032221 Rpd3S complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yi3, PDBe:7yi3, PDBj:7yi3
PDBsum7yi3
PubMed37468628
UniProtQ04779|RCO1_YEAST Transcriptional regulatory protein RCO1 (Gene Name=RCO1)

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