Structure of PDB 7xvj Chain D Binding Site BS01

Receptor Information
>7xvj Chain D (length=377) Species: 746128 (Aspergillus fumigatus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIAYHTLTKALLFPDIDQYQHWHHVAPMLAKMLVDGKYSIHQQYEYLCLF
AQLVAPVLGPYPSPGRDVYRCTLGGNMTVELSQNFQRSGSTTRIAFEPVR
YQASVGHDRFNRTSVNAFFSQLQLLVKSVNIELHHLLSEHLTLTAKDERN
LNEEYLTNFQVKTQYVVALDLRKTGIVAKEYFFPGIKCAATGQTGSNACF
GAIRAVDKDGHLDSLCQLIEAHFQQSKIDDAFLCCDLVDPAHTRFKVYIA
DPLVTLARAEEHWTLGGRLTDEDAAVGLEIIRGLWSELGIIQGLLPIMLN
YEMKAGQRLPKPKLYMPLTGIPETKIARIMTAFFQRHDMPEQAEVFMENL
QTRYQAWLSFAYTKEKGPYLSIYYFWP
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain7xvj Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xvj Enzymatic formation of a prenyl beta-carboline by a fungal indole prenyltransferase.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R129 K219 Y221 Y288 K364 Y366
Binding residue
(residue number reindexed from 1)		R93 K179 Y181 Y248 K313 Y315
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.-
3.4.11.17: tryptophanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004659 prenyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0006508 proteolysis
GO:0009820 alkaloid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7xvj, PDBe:7xvj, PDBj:7xvj
PDBsum7xvj
PubMed35767141
UniProtD1D8L6|CDNTP_ASPFM Cyclic dipeptide prenyltransferase (Gene Name=cdpNPT)

[Back to BioLiP]