Structure of PDB 7xlq Chain D Binding Site BS01

Receptor Information
>7xlq Chain D (length=955) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNAR
QLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYN
AKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGS
TIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDN
SRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSV
SEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNIT
AKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKY
NKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEY
LDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENK
TNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPN
LQPKPIGVGIPTQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTL
VKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQ
ARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKT
PNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGIT
RVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESG
IMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRMDCVILDDGG
FLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPG
AASKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIM
VESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLED
YTDCG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7xlq Chain D Residue 1206 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7xlq Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S261 S263
Binding residue
(residue number reindexed from 1)		S235 S237
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0046872 metal ion binding
GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential
Biological Process
GO:0006816 calcium ion transport
GO:0051924 regulation of calcium ion transport
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060402 calcium ion transport into cytosol
GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0070588 calcium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0098703 calcium ion import across plasma membrane
GO:0098903 regulation of membrane repolarization during action potential
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1904646 cellular response to amyloid-beta
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016529 sarcoplasmic reticulum
GO:0030315 T-tubule
GO:0034702 monoatomic ion channel complex
GO:0048787 presynaptic active zone membrane
GO:0070062 extracellular exosome
GO:0098982 GABA-ergic synapse
GO:0098992 neuronal dense core vesicle
GO:1990454 L-type voltage-gated calcium channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xlq, PDBe:7xlq, PDBj:7xlq
PDBsum7xlq
PubMed36720859
UniProtP54289|CA2D1_HUMAN Voltage-dependent calcium channel subunit alpha-2/delta-1 (Gene Name=CACNA2D1)

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