Structure of PDB 7xd9 Chain D Binding Site BS01

Receptor Information

>7xd9 Chain D (length=622) Species: 11060 (dengue virus type 2)

ESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSA
SSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPK
EGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDEN
KWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGK
AKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGY
ILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEA
IFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEA
QLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVV
KPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELI
MKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYF
HRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVW
IQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAI
NQVRSLIGNEEYTDYMPSMKRF

Ligand information

>7xd9 Chain E (length=13)

aacgauuauaucc

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xd9 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Resolution: 2.58 Å
• Binding residue (original residue number in PDB): K402 R404 A408 L409 M455 K457 I474 Y476 R482 N493 E508 G509 G511 G602 V604 W803 M804 V812 R815
• Binding residue (residue number reindexed from 1): K135 R137 A141 L142 M188 K190 I207 Y209 R215 N226 E241 G242 G244 G335 V337 W536 M537 V545 R548

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd9, PDBe:7xd9, PDBj:7xd9
• PDBsum: 7xd9
• PubMed: 36577062
• UniProt: Q91H74