Structure of PDB 7xd8 Chain D Binding Site BS01

Receptor Information

>7xd8 Chain D (length=621) Species: 11060 (dengue virus type 2)

SETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSAS
SMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKE
GTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENK
WKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKA
KGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYI
LRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAI
FKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQ
LIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVVK
PLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIM
KDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFH
RRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWI
QENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAIN
QVRSLIGNEEYTDYMPSMKRF

Ligand information

>7xd8 Chain E (length=11)

cgauuauaucc

...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): K402 R404 A408 M455 K457 I474 Y476 R482 N493 G509 G602 V604 W803 M804 V812 R815
• Binding residue (residue number reindexed from 1): K134 R136 A140 M187 K189 I206 Y208 R214 N225 G241 G334 V336 W535 M536 V544 R547

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
• PDBsum: 7xd8
• PubMed: 36577062
• UniProt: Q91H74