Structure of PDB 7x75 Chain D Binding Site BS01

Receptor Information
>7x75 Chain D (length=1259) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPTR
DWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWY
FKGVPSRLGYLLDLAPKDLEKVIYFAAYMITFVDEERRTRDLPSLEAHVS
VERQQIEQRRDSDLEARAKKLETDLAELEAEGAKADVRRKVREGAEREMK
QLRDRAQREIDRLDEVWNRFKNLKVQDLEGDELLYRELRDRFGTYFDGSM
GAAALQKRLESFDLDEEAERLREIIRTGKGQKKTRALKRLKVVSAFLQTS
NSPKGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKR
LLDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDML
KGKQGRFRQNLLGKRVDYSARSVIVVGPQLKLHQCGLPKAMALELFKPFV
MKRLVDLNHAQNIKSAKRMVERGRTVVYDVLEEVIAEHPVLLNRAPTLHR
LGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHLPLSAEAQAEAR
ILMLSSNNILKPADGRPVTMPTQDMVLGLFFLTTDSEGRSPKGEGRAFGS
SAEAIMAFDAGDLTLQAKIDIRFPVGTIPPRGFEPPAREEGEPEWQQGDT
FTLKTTLGRALFNELLPEDYPFVDYEVGKKQLSEIVNDLAERYPKVIVAA
TLDNLKAAGFFWATRSGVTVAISDIVVPDAKKEIVKGYEGQDEKVQKQYE
RGLITKEERTQELIAIWTKATNEVAEAMNDNFPKTNPVSMMVNSGARGNM
MQMRQIAGMRGLVSNAKNETIPRPIKASFREGLSVLEYFISTHGARKGLA
DTALRTADSGYLTRRLVDVSQDVIIREEDCGTERGLKLPIATRDADGTLR
KAEDVETSVYARMLAEDVVIDGKVIAPANVDLGDVLIDALVAHGVEEVKT
RSILTCESQVGTCAMCYGRSLATGKLVDIGEAVGIIAAQSIGEPGTQLTM
RTFHTGGVAGDDITQGLPRVVELFEARTPKGVAPISEASGRVRIEETEKT
KKIVVTPDDGSDETAFPISKRARLLVGEGDHVEVGQKLTVGATNPHDVLR
ILGQRAVQVHLVGEVQKVYNSQGVSIHDKHIEIIIRQMLRRVTIIESGDA
ELLPGELVERTKFETENRRVVQEGGHPASGRPQLMGITKASLATESWLSA
ASFQETTRVLTDAAINAKSDSLIGLKENVIIGKLIPAGTGLSRYRNIRVE
PTEEAKAAM
Ligand information
>7x75 Chain O (length=84) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caaggcacatgacaacggtgttcagtgccgcgttgcccgataccccctac
ccgtagttgactggcatccgggcgccgggtcgcc
Receptor-Ligand Complex Structure
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PDB7x75 Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		Y36 R37 R291 K294 R1033
Binding residue
(residue number reindexed from 1)		Y30 R31 R285 K288 R1027
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x75, PDBe:7x75, PDBj:7x75
PDBsum7x75
PubMed35871291
UniProtQ8CJT1|RPOC_STRCO DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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