Structure of PDB 7wiy Chain D Binding Site BS01

Receptor Information

>7wiy Chain D (length=340) Species: 9606 (Homo sapiens)

VPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG
YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYC
GYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDED
VQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAF
DPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPY
TQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 7wiy Chain D Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wiy Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2.
• Resolution: 3.09 Å
• Binding residue (original residue number in PDB): H318 H323 E363
• Binding residue (residue number reindexed from 1): H168 H173 E213
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.14.16.4: tryptophan 5-monooxygenase.

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0004510 tryptophan 5-monooxygenase activity
• GO:0005506 iron ion binding
• GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
• GO:0046872 metal ion binding

Biological Process

• GO:0009072 aromatic amino acid metabolic process
• GO:0042427 serotonin biosynthetic process

Cellular Component

• GO:0005829 cytosol
• GO:0043005 neuron projection

External links

• PDB: RCSB:7wiy, PDBe:7wiy, PDBj:7wiy
• PDBsum: 7wiy
• PubMed: 36046836
• UniProt: Q8IWU9|TPH2_HUMAN Tryptophan 5-hydroxylase 2 (Gene Name=TPH2)