Structure of PDB 7whu Chain D Binding Site BS01

Receptor Information

>7whu Chain D (length=218) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRA
VRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATI
NANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTS
LCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYP
DAFAPVAQFVNWIDSIIQ

Ligand information

>7whu Chain H (length=8) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

VSSPVSTM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7whu Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide
Resolution	2.89 Å
Binding residue (original residue number in PDB)	C177 F178 S181 S196 F197 V198 G200
Binding residue (residue number reindexed from 1)	C169 F170 S173 S188 F189 V190 G192

Enzymatic activity

Enzyme Commision number

3.4.21.37: leukocyte elastase.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:7whu, PDBe:7whu, PDBj:7whu
PDBsum	7whu
PubMed
UniProt	P08246\|ELNE_HUMAN Neutrophil elastase (Gene Name=ELANE)

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