Structure of PDB 7vqo Chain D Binding Site BS01

Receptor Information
>7vqo Chain D (length=1180) Species: 83333,759272 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGETFDVKGPRPNDYPLRAPKPVGQLISHIYKDRIAQFYNGGQYEHQNLR
AMMKEDSVSGEPHVQLWVWHAPGQTRPSFEEAVSNQFVKTNVGEWFGPSW
TTHWFRVVLTVPEHLQNKRLLEFHWDSNSEGLVWSEDGKPLQGLTGGGER
VEWILPDSFRDGKEHTIYIEMACNRMFGNAPGGDSIQPPDPNKYFRLDKA
EIVAIDPDARQLWIDIWILQDAAREFPGDSWESHKALQVCNEIIEAFELG
NRESLKKCRKIAEQYLGPNVDSPNVYNSGKEPLVYAIGHCHIDSCWLWPF
AETKRKVVRSWSSQCDLMDRYPELNFVCSQAQQYKWLKQLYPYAFERVKK
KVAEGRFHPIGGSWVEHDTNMPSGESLVRQFLYGQRFYESNFGKRCKTFW
LPDTFGYSAQLPQLCRLAGMTRFLTQKLSWNNINRFPHTTFNWVALDGSQ
VICHMPPSETYTAEAHFGDVKRSMSQHKSLDQDNTSLLVFGKGDGGGGPT
WVQIEKLRRCRGISDTVGLLPRVHMGSSVDDFFDRLERKADTFVTWYGEL
YFELHRGTYTTQAKNKKNNRRAEAKLRDLELLATIASVQDKSYKYPKEEF
DAMWENVLLCQFHDCLPGSSIEMAYRESDQMYADVFSTAEKIMKGVSQVL
GLEPALNHMSTTNTVALNTLPWPRRELVKISEKEAAVAHGTGPFLKLQKL
ETTKPLVTLRQVTKGAFVLENSQLRVHVEKGVITSLYDKQANREVIPKGQ
KANQYVIFDDKPLYWQAWDVEVYHLDTRKELPSGETEVHENTPHRVSVVT
RTKVSDKSHIQTIIALNGAVEGEQSWVEVQSKVDWHETMKFLKVEFPVDV
RNTEASYETAFGIVRRPTHYNTSWDMAKFEVCAHRWADLSEYGYGVSILN
DSKYGFATAGQTMRLSLLRSPKAPDAHADMGTHHIRWAILPHQGSLSHVT
IRKAFEFNNPTKLYSSPDAAALVAAPPPVWLTPDSSPAIVLDTVKRGEDD
EDVSRGELPARKGQSVILRMYDSLGGLARGTVVTTWPLKKVCKVNLLEDD
LEVVPWENGRFTVELRPFEVASYRLVLALEATFVRDTVQDGTVLAPNHLF
EQTWVLRNTGKVAWPAGCSVKFVGGDYMGRVAVQPGEEAPFTVLLRTPYR
ACRVISHWRLTTPKGTKFGHRLWCDVVVEK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7vqo Chain D Residue 1701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7vqo Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1
Resolution2.19 Å
Binding residue
(original residue number in PDB)		H292 D294 D404 H614
Binding residue
(residue number reindexed from 1)		H291 D293 D403 H613
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.24: alpha-mannosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004559 alpha-mannosidase activity
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
GO:1901982 maltose binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0009313 oligosaccharide catabolic process
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vqo, PDBe:7vqo, PDBj:7vqo
PDBsum7vqo
PubMed
UniProtG0SE85;
G0SGP6;
P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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