Structure of PDB 7vok Chain D Binding Site BS01

Receptor Information
>7vok Chain D (length=376) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHVNIGTIGHVDHGKTTLTAAITKVLHETKAFDQIDNAPEERQRGITIN
IAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMP
QTREHVLLARQVGVPYILVADAVDDEELLELVEMEVRELLAAQEFDEDAP
VVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVF
TITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQ
GQAGDNVGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGG
RHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVA
MDEGLRFAIREGGRTVGAGRVTKIIK
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain7vok Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7vok The Crystal structure of EF-Tu and GDP from Mycobacterium tuberculosis
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D22 G24 K25 T26 T27 S175 A176 L177
Binding residue
(residue number reindexed from 1)		D13 G15 K16 T17 T18 S155 A156 L157
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0035375 zymogen binding
Biological Process
GO:0001666 response to hypoxia
GO:0006412 translation
GO:0006414 translational elongation
GO:0010039 response to iron ion
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vok, PDBe:7vok, PDBj:7vok
PDBsum7vok
PubMed36192483
UniProtP9WNN1|EFTU_MYCTU Elongation factor Tu (Gene Name=tuf)

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