Structure of PDB 7usf Chain D Binding Site BS01

Receptor Information

>7usf Chain D (length=235) Species: 11757 (Mouse mammary tumor virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LESAQESHALHHQNAAALRFQFHITREQAREIVKLCPNCPLKPRVLWQMD
VTHVSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVLQHLAQSFAYMGI
PQKIKTDNAPAYVSRSIQEFLARWKISHVQAIVERTHQNIKAQLNKLQKY
YTPHHLLAHALFVLNHVNMDNQGHTAAERHWGPMVMWKDLLTGSWKGPDV
LITAGRGYACVFPQDAESPIWVPDRFIRPFTERKE

Ligand information

>7usf Chain I (length=22) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aatgccgcagtcggccgacctg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7usf B-to-A transition in target DNA during retroviral integration.
Resolution	3.5 Å
Binding residue (original residue number in PDB)	R240 G241 Y242 W255 R259
Binding residue (residue number reindexed from 1)	R206 G207 Y208 W221 R225

Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0008270	zinc ion binding

	Biological Process
GO:0015074	DNA integration

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Molecular Function

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Biological Process

External links

PDB	RCSB:7usf, PDBe:7usf, PDBj:7usf
PDBsum	7usf
PubMed	35947647
UniProt	P03365\|POL_MMTVB Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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