Structure of PDB 7uoe Chain D Binding Site BS01

Receptor Information
>7uoe Chain D (length=186) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAM
QRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNN
IINNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWE
IQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA
Ligand information
>7uoe Chain P (length=33) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cguagcaugcuacgucauucuccacgcgaagca
.................................
Receptor-Ligand Complex Structure
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PDB7uoe Structural basis for substrate selection by the SARS-CoV-2 replicase.
Resolution2.67 Å
Binding residue
(original residue number in PDB)		K36 R51 A54
Binding residue
(residue number reindexed from 1)		K31 R46 A49
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008242 omega peptidase activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:7uoe, PDBe:7uoe, PDBj:7uoe
PDBsum7uoe
PubMed36725929
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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