Structure of PDB 7uiy Chain D Binding Site BS01

Receptor Information

>7uiy Chain D (length=580) Species: 562 (Escherichia coli)

TENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGV
GKTAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFK
ALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRV
IGSTTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAH
HDVRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRK
KTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIE
ALTEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLR
FDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEK
AHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIG
LIHQDNSTDAMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVE
LQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLAN
ELLFGSLVDGGQVTVALDKEKNELTYGFQS

Ligand information

>7uiy Chain S (length=11) Species: 562 (Escherichia coli)

EKVRDALKPPS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7uiy AAA+ protease-adaptor structures reveal altered conformations and ring specialization.
• Resolution: 3.22 Å
• Binding residue (original residue number in PDB): Y259 R260 A293 A296 S297
• Binding residue (residue number reindexed from 1): Y91 R92 A125 A128 S129

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006508 proteolysis
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
• GO:0006979 response to oxidative stress
• GO:0034605 cellular response to heat
• GO:0043335 protein unfolding

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0009368 endopeptidase Clp complex

External links

• PDB: RCSB:7uiy, PDBe:7uiy, PDBj:7uiy
• PDBsum: 7uiy
• PubMed: 36329286
• UniProt: P0ABH9|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)