Structure of PDB 7uin Chain D Binding Site BS01

Receptor Information
>7uin Chain D (length=387) Species: 39491 (Agathobacter rectalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLMEQILSSDNLNRAYLQVVRNKGAEGVDGMKYTELKEHLAKNGETIKGQ
LRTRKYKPQPGVPTVTDRFIQQAIAQVLTPIYEEQFHDHSYGFRPNRCAQ
QAILTALNIMNDGNDWIVDIDLEKFFDTVNHDKLMTLIGRTIKDGDVISI
VRKYLVSGGNLSPLLANIMLNELDKEMEKRGLNFVRYADDCIIMVGSEMS
ANRVMRNISRFIEEKLGLKVNMTKSKVDRPSGLKYLGFGFYFDPRAHQFK
AKPHAKSVAKFKKRMKELTCRSWGVSNSYKVEKLNQLIRGWINYFKIGSM
KTLCKELDSRIRYRLRMCIWKQWKTPQNQEKNLVKLGIDRNTARRVAYTG
KRIAYVCNKGAVNVAISNKRLASFGLISMLDYYIEKC
Ligand information
>7uin Chain B (length=541) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugcgcgccaugggcgcgcucuaacggguguaagucccgaacaugccc
agguagugggaaauguauagccgaacagcaagggugucuacugugaggug
gaaucugaaggaagcuguaagcgaaucucugguccgacggacagaaaucg
cauauaaggcuaggcuucggugauaagcuggcaaagaacagugaagucua
auaacugaagcagaguaaaugcggcggauauauggagagaaagagcgugc
accuuaagcguggaggucucacagagguuagccuaguaacaacgaacugu
gagaagucagccgagcccauaguagugaagaagucucuguaauggggaug
gagcgaaggggcgaacaaucauaaugucucguauugcagaaaugacaaca
ucugccguaaccaaucggguaaaagguggucaaaucaagcgagacggaaa
ggaguugauugaaccgccguauacggaaccguacguacgguggugugaga
ggucggaauuucucaauuaagagaaauucuuccuacucgau
.....<<<<<...<<<<<<<<<<<..<<<<.......>>>>.<<<<.<<<
....(((>>>..>>>>...<<....<<<<..<<<<.<<<<<<....>>>>
>>>>>>.......>>>>...>>...<<<<<<<<<<<...........<<<
<<......<<<..<<<<<...<<<..<<<<........>>>>...>>>..
...)))>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>
.>>....>>>>>..<.<<<<<<<<<<<<..>>>>.<......>...>>>>
>>>>..>....<..<<<<......<<......<<<<<<.....>>>>>>.
..>>....>>>>>..<<<<<<...<.<.<<<<.<<<<.<<..<<<<..<<
<<<.<<<........>>>.....>>>>>>>>>..>>..>>>>.>>>>.>.
.>...>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<
<<..<<<<<<<<<<......>>>>>>>>>>.>>>.>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uin Structures of a mobile intron retroelement poised to attack its structured DNA target
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R58 D152 K153 T156 R160 I168 S169 R172 R217 S234 E235 M236 S237 R240 V241 R243 N244 R247 K303 R308 S309 R347 R351 M354 K358 R389 A391 N395
Binding residue
(residue number reindexed from 1)		R54 D132 K133 T136 R140 I148 S149 R152 R180 S197 E198 M199 S200 R203 V204 R206 N207 R210 K266 R271 S272 R310 R314 M317 K321 R352 A354 N358
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003964 RNA-directed DNA polymerase activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006974 DNA damage response

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7uin, PDBe:7uin, PDBj:7uin
PDBsum7uin
PubMed36356138
UniProtA0A173ZME3

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