Structure of PDB 7udu Chain D Binding Site BS01

Receptor Information
>7udu Chain D (length=701) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFAI
YGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSG
KTEATKLILRCLAAMNQRRDVMQQIKILEATPLLEAFGNAKTVRNDNSSR
FGKFVEIFLEGGVICGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLP
AQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSE
DQDSIFRILASILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSP
EGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITR
VNALVSPKQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIV
FQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRILDDQCCFPQA
TDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNH
DQVRQDVLDLFVHSRTRVVAHLFSSHAAQTYKAHTVAAKFQQSLLDLVEK
MERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKVRLPF
QVFIDRYRCLVALKLNVPADGDMCVSLLSRLCTVTPDMYRVGISKLFLKE
HLHQLLESMRERVQNRAALTLQRYLRGFFIQRHFRSLRRKIILLQSRARG
F
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7udu Chain D Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7udu Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia.
Resolution4.15 Å
Binding residue
(original residue number in PDB)		N1247 P1248 G1302 G1304 K1305 T1306 E1307
Binding residue
(residue number reindexed from 1)		N43 P44 G98 G100 K101 T102 E103
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7udu, PDBe:7udu, PDBj:7udu
PDBsum7udu
PubMed35857845
UniProtQ9QZZ4|MYO15_MOUSE Unconventional myosin-XV (Gene Name=Myo15a)

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