Structure of PDB 7u60 Chain D Binding Site BS01

Receptor Information

>7u60 Chain D (length=469) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPE
SIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSI
QVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIG
FGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTR
FNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDA
KTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQK
NINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIR
SKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAK
VRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGN
GTFECGVCRCGPGWLGSQC

Ligand information

>7u60 Chain N (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RGDFV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7u60 A general chemical principle for creating closure-stabilizing integrin inhibitors.
Resolution	2.55 Å
Binding residue (original residue number in PDB)	S121 Y122 S123 N215 A218
Binding residue (residue number reindexed from 1)	S119 Y120 S121 N213 A216

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7u60, PDBe:7u60, PDBj:7u60
PDBsum	7u60
PubMed	36113427
UniProt	P05106\|ITB3_HUMAN Integrin beta-3 (Gene Name=ITGB3)

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