Structure of PDB 7u2n Chain D Binding Site BS01

Receptor Information
>7u2n Chain D (length=345) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PMPPSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTM
DYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGA
NFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQL
ESFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGK
FTCIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLG
ITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNF
IARQVEEMRKLFISRAKRIDTVSRVAFPLVFLIFNIFYWITYKII
Ligand information
Ligand IDL2L
InChIInChI=1S/CH5NO3S/c2-1-6(3,4)5/h1-2H2,(H,3,4,5)
InChIKeyOBESRABRARNZJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7C(N)S(=O)(=O)O
ACDLabs 12.01NCS(=O)(=O)O
CACTVS 3.385NC[S](O)(=O)=O
FormulaC H5 N O3 S
Nameaminomethanesulfonic acid
ChEMBLCHEMBL1741886
DrugBank
ZINCZINC000008034708
PDB chain7u2n Chain D Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7u2n A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state
Resolution2.8 Å
Binding residue
(original residue number in PDB)		F79 R81 S145
Binding residue
(residue number reindexed from 1)		F57 R59 S123
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0016594 glycine binding
GO:0016934 extracellularly glycine-gated chloride channel activity
GO:0022824 transmitter-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u2n, PDBe:7u2n, PDBj:7u2n
PDBsum7u2n
PubMed
UniProtO93430|GLRA1_DANRE Glycine receptor subunit alphaZ1 (Gene Name=glra1)

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