Structure of PDB 7tho Chain D Binding Site BS01

Receptor Information

>7tho Chain D (length=471) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCA
PESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNF
SIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLR
IGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQV
TRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT
DAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLS
QKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGK
IRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIE
AKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNN
GNGTFECGVCRCGPGWLGSQC

Ligand information

>7tho Chain M (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

CRGDWPC

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7tho A general chemical principle for creating closure-stabilizing integrin inhibitors.
Resolution	2.75 Å
Binding residue (original residue number in PDB)	W129 Q132
Binding residue (residue number reindexed from 1)	W129 Q132

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7tho, PDBe:7tho, PDBj:7tho
PDBsum	7tho
PubMed	36113427
UniProt	P05106\|ITB3_HUMAN Integrin beta-3 (Gene Name=ITGB3)

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