Structure of PDB 7sbn Chain D Binding Site BS01

Receptor Information
>7sbn Chain D (length=406) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLPSLEDLLFYTIAEQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLT
LQTTSVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYES
AKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSC
VKPLKYAIAVNDLGTEYVHRYVGKEPSGLRLFLNEDDKPHNPMVNAGAIV
VTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFA
IGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFC
PITGERVLSPEAVRNTLSLMHSCGMWDFSGQFAFHVGLPAKSGVAGGILL
VVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREG
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain7sbn Chain D Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sbn High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
Resolution2.14 Å
Binding residue
(original residue number in PDB)		Y249 Q285 S286 N335 E381 N388 Y414 G483 V484
Binding residue
(residue number reindexed from 1)		Y112 Q148 S149 N195 E241 N248 Y274 G343 V344
Annotation score5
Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7sbn, PDBe:7sbn, PDBj:7sbn
PDBsum7sbn
PubMed34999118
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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