Structure of PDB 7s00 Chain D Binding Site BS01

Receptor Information

>7s00 Chain D (length=481) Species: 1815509 (Bacillus phage AR9)

MEKTYNLNDILLSNEYEKIKEDIKEEIINDMASKKVKYSNTSEFAKNDFL
KDEFIDLVVDGETYEITYGNLITLLIVARPFNHFKVPMTEDLLFDLSDLK
EYQNYYTTLLEHFGYSNEIKSIIKDVISELAIFSGDINVTFGNTVSIKSL
IDLGNKVKRFRELLHYRLPNDEALEFNDIEAIIKKNLDEIMKILSETDNM
LRYYIDSGAGINSKQFGQVLSLVGSKPDLFGKIIPYPINTSFLRGLDVRS
FYINALGARKALITNYQQVRNSGYLTRKISMLLMDTKLIDLDDCGSHENN
YLSINVENKDVLKRFSKRSYLNNNGELVEIDINDESLIGQVIKIPSPTTC
ASNEGVCRKCYGKLFDINKDLNIGMIAVLLLTDPLTQRLLSAKHLELSKP
LREIKDLIETNKYIKDHNVNEVVNYFIYLLNESGINIQSVHSELIIREMM
KLDDSDRTQFKNDKMPDYEIFRITDANLKGD

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7s00 Chain D Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7s00 Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): C350 C360
• Binding residue (residue number reindexed from 1): C350 C360
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.6: DNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003899 DNA-directed 5'-3' RNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex

External links

• PDB: RCSB:7s00, PDBe:7s00, PDBj:7s00
• PDBsum: 7s00
• PubMed: 35725571
• UniProt: A0A172JI62