Structure of PDB 7re0 Chain D Binding Site BS01

Receptor Information
>7re0 Chain D (length=185) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQ
RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNI
INNARDGCVPLNIIPLTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEI
QQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA
Ligand information
>7re0 Chain T (length=37) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaauagcuucuuaggagaaugacguagcaugcuacgc
.....................................
Receptor-Ligand Complex Structure
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PDB7re0 Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K61 Q65
Binding residue
(residue number reindexed from 1)		K55 Q59
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008242 omega peptidase activity
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:7re0, PDBe:7re0, PDBj:7re0
PDBsum7re0
PubMed35260847
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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