Structure of PDB 7rdq Chain D Binding Site BS01

Receptor Information
>7rdq Chain D (length=1366) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGP
IKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHI
WFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQL
LTDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGV
ALYRFPRRVRVEYVKKEWTEPKDYRVQPHMNVVVPEGARVEAGDKIVAAI
DPEEEVIAEAEGVVHLHEPASILVVKARVYPFEDDVEVSTGDRVAPGDVL
ADGGKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLE
ALEKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLP
PDLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEK
RMLQEAVDALLDNGRRGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLGK
RVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVK
AARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLV
EGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLS
PASGEPLAKPSRDIILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEV
ALNAPIKVAGRETSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGK
RLETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLR
LGMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQYLEEADRKL
LQIEQAYEMGFLTDRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPLY
VMAQSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYF
ISSHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVP
LFQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEEGRYLSMDDV
HLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAV
GIVAAQSIGEPGTQLTTQGLPRVIELFEARRPKAKAVISEIDGVVRIEET
EEKLSVFVESEGFSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLL
EAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGD
SRLLEGQVLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLS
AASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQV
VDQKTLKAIEEARKEA
Ligand information
Receptor-Ligand Complex Structure
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PDB7rdq Structural and mechanistic basis of reiterative transcription initiation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R586 S596 K610 R615 R622 T1088 A1089 Q1441 N1442
Binding residue
(residue number reindexed from 1)		R465 S475 K489 R494 R501 T967 A968 Q1305 N1306
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rdq, PDBe:7rdq, PDBj:7rdq
PDBsum7rdq
PubMed35082149
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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