Structure of PDB 7r2m Chain D Binding Site BS01

Receptor Information
>7r2m Chain D (length=417) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAAL
DGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQGS
AYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIA
FAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLG
TDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMV
ALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSV
PHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFAD
RLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQD
TKGDYQKALLYLCGGDD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r2m SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		L23 F25 N26 I27 V28 Q33 S45 H78 V82 F85 R86
Binding residue
(residue number reindexed from 1)		L18 F20 N21 I22 V23 Q28 S40 H73 V77 F80 R81
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding

View graph for
Molecular Function
External links
PDB RCSB:7r2m, PDBe:7r2m, PDBj:7r2m
PDBsum7r2m
PubMed38142947
UniProtP57105|SYJ2B_HUMAN Synaptojanin-2-binding protein (Gene Name=SYNJ2BP)

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