Structure of PDB 7qiw Chain D Binding Site BS01

Receptor Information
>7qiw Chain D (length=251) Species: 4081 (Solanum lycopersicum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRVIRAQRKGAGSVFKSHTHHRKGPARFRTLDFGERNGYLKGVITEVIHD
PGRGAPLARVTFRHPFRYKHQKELFVAAEGMYTGQFVYCGKKATLMVGNV
LPLRSIPEGAVVCNVEHKVGDRGVFARCSGDYAIVISHNPDNGTTRVKLP
SGAKKIVPSGCRAMIGQVAGGGRTEKPMLKAGNAYHKYRVKRNCWPKVRG
VAMNPVEHPHGGGNHQHIGHASTVRRDAPPGQKVGLIAARRTGRLRGQAR
A
Ligand information
>7qiw Chain 2 (length=3098) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgaccccaggucaggcgggauuacccgcugaguuuaagcauaucaauaa
gcggaggaaaagaaacuuacaaggauuccccuaguaacggcgagcgaacc
gggaacagcccagccuuagaaucgggcggcuccgucguccgaauuguagu
cuggagaagcguccucagcggcggaccgggcccaaguccccuggaagggg
gcgccggagagggugagagccccgucgugcccggacccugucgcaccacg
aggcgcugucuacgagucggguuguuugggaaugcagcccaaaucgggcg
gugaauuccguccaaggcuaaauacuggcgagagaccgauagcgaacaag
uaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagugc
uugaaauugucgggagggaagcggaugggggccggcgaugcgccccgguc
gguguggaacggcgagccgguccgccgaucgacucggggcguggaccagc
guggauugggggggcggccaaagcccgggcucucgauacgcccguggaac
gccgucuccccgauuguggaaggcagcgcgcgccuccggcgugcuucggc
aucugcgcgcuccggacgcuggccugugggcuccccauucgacccgucuu
gaaacacggaccaaggagucugacaugugugcgagucaacgggcgaguaa
acccguaaggcguaaggaagcugauuggugggaucccccugaggggugca
ccgccgaccgaccuugaucuucugagaaggguucgagugugagcauaccu
gucgggacccgaaagauggugaacuaugccugagcggggcgaagccagag
gaaacucugguggaggcccgcagcgauacugacgugcaaaucguucgucu
gacuuggguauaggggcgaaagacuaaucgaaccgucuaguagcugguuc
ccuccgaaguuucccucaggauagcuggagcucgcgugcgaguucuaucg
gguaaagccaaugauuagaggccucggggccucgaccuauucucaaacuu
uaaauagguaggacggcgcggcugcuuuguugagccgcgccacggaauca
agagcuccaagugggccauuuuugguaagcagaacuggcgaugcgggaug
aaccggaagccggguuacggugccaaacugcgcgcuaaccuagaucccac
aaaggguguuggucgauuaagacagcagcugccgaaucaacuagccccga
aaauggauggcgcuuaagcgcgcgaccuacacccggccgucggggcaagu
gccaggccccgaugaguaggagggcgcggcggucgcugcaaaaccuuggg
cgcgagccugggcggagcggccgucggugcagaucuuggugguaguagca
aauauucaaaugagaacuuugaaggccgaagaggggaaagguuccaugug
aacggcacuugcacauggguuagucgauccuaagggucgggggaaccccg
acagauagcgcgucgcgcguacuccgaaagggaaucggguuaaaauuccu
gaaccgggacguggcgguugacggcaacguuaggaaguccggagacgucg
gcgggagccucgggaagaguuaucuuuucuguuuaacagccugcccaccc
uggaaucggcucagccggagguaggguccagcggcuggaagagcaccgca
cgugguguccggugcgcucccggcggcccuugaaaauccggaggaccgaa
ugccguccacgcccggucguacucauaaccgcaucaggucuccaagguga
acagccucuggucgauggaacaauguaggcaagggaagucggcaaaaugg
auccguaacuucgggaaaaggauuggcucugagggcuggacagccaacuc
agaacugguacggacaaggggaauccgacuguuuaauuaaaacaaagcau
ugcgauggucccaacggauguuuacgcaaugugauuucugcccagugcuc
ugaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggagua
acuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacg
cgcaugaauggauuaacgagauucccacugucccugucuacuauccagcg
aaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagac
ccuguugagcuugacucuaguccgacuuugugaaaugacguuauuuuacu
uauuccgugaaucggaagcggguuuuuggacccaaggcucgcuucgcggg
ccgauccgggcggaagacauugucagguggggaguuuggcuggggcggca
caucuguuaaaagauaacgcagguguccuaagaugagcucaacgagaaca
gaaaucucguguggaacagaaggguaaaagcucguuugauucugauuucc
aguacgaauacgaaccgugaaagcguggccuaacgauccuuuagaccuuc
ggaauucgaagcuagaggugucagaaaaguuaccacagggauaacuggcu
uguggcagccaagcguucauagcgacguugcuuuuugauccuucgauguc
ggcucuuccuaucauugugaagcagaauucaccaaguguuggauuguuca
cccaccaauagggaacgugagcuggguuuagaccgucgugagacagguua
guuuuacccuacugaugacagugucgcaauaguaauucaaccuaguacga
gaggaaccguugauucacacaauuggccaucgcgcuugguugaaaagcca
guggcgcgaagcuaccgugugcuggauuaugacugaacgccucuaaguca
gaauccgggcuagaagcgacgcaugcgcccgccguccggccgacccgcag
uaggggccggcccccaagggcacgugucguuggcuaagucgccgcgacgg
aagcgucgcggugaccgccuugaaguacaauuuccaucgagcggcgggua
gaauccuuugcagacgacuuaaacgcgacgggguauuguaaguggcagag
uggccgccacgauccacugagauucagcccuuugucgcuccgauucgu
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<.......<.....>......
>>>>>..[[[..<.<......<<<<<<<<<...>>>>>>>>>......>.
>...<<<<<<<<.<<<.<<<<<<<.<<<<<<.<....<<<<......>>>
>.((......<<<.....))>>>...>.>>>>>>...>>>>>>>.....>
>>>>>>>.>>>.......<<<<<<<........>>>>>>>.....(((((
..<<<<<<)))))..]]]................................
..<<....>>...............<<<<....>>>>.............
.....................<<<<<<<<<<<<......<<<<<<<<<<<
<..<<<<<.<<<<..>>>>.>>>>>....>>>>.>>>>>>>>.<.<<<<<
<..<<<<<<<<<<<<<<<.....<<<<<<<.........>>>>>.>>...
>>>>>>>>>>>>>>>.........<<<<<<<<<<...>>>..<<....>>
....>>>>>>>.....>>>>>>.>....>>>.>>>>>>>>>..<<<<...
.....>>>><<<<<<...<<<<<<<.<<<<<<..<<<..<<<<.......
.>>>>...>>>...<<....>>....<<<<<...<<<<....>>>>....
>>>>>.<<<<<<<....<<....>>....>>.>>>.>>....>>>>>>.>
>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<
....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>..
..>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<
<<<<<....<.<<<....>>>.><<<<<<<<<<......<<.<<<<<<<.
....<<<....<<<..<.<<<..<<<<<..>>>>>>>>.>..>>>..>.>
>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>.
.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<....
..>>>...<<<<<<<...<<<(((.....<<<<<<.......<.......
...<<<.<<<<<<.<<<.......<<....>>...>>>.>>>>>>>>>..
........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<....
.....>>>>>>>>>....>>>>>><.<<<<<<<<<<.......<<<.<<<
<....>>>>>>>....>>>>>>>>>>..>.....>>>>>><<.....<<.
....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<.
..<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.
.......<<<<<.>>>>>.....>>....>>...<<<<<........>>>
>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<
.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<
<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<<<<.
.>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>....
..>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<..
...>>>>..>>>>..<<<<.....<<<<<<<.<<...............<
<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>
>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<
<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<
...<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.
......>>>>>>........<...........<<<<<.......>>>>>.
....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>.
...>>....<<<<<........>>>>>....[[[[[..{{{.{{......
[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<<<..>>>>>>>>>.
..<<<<<.....<<<<...................<<<<<<<...>>>>>
>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>.
.<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<...
....>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<..
.....>>>>.>>>>.<<<....>>>.>>))).......((((((..((((
.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<
.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<
<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<........
.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>.
...}}..}}}.]]]]]....<<<<<<<..<<<<...<<<<<.........
........>>>>>..<<<<<...<<<<....<<<<<<<<<......>>>>
..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>
...>>>>.>>>>...>>>>>>>....<<<<<<<<<.<<.....<<.....
..<<<<<..>>>>>....>>...........<<<...<<<<<<<<<<<..
....>>>>>>>>>>>.>>>..................>>.>>>>>>>>>.
<<<<<.<.............>...<<<<<<<<<.<<<....<<<<.<..<
<<<<.>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qiw Cryo-EM structure and rRNA modification sites of a plant ribosome.
Resolution2.35 Å
Binding residue
(original residue number in PDB)
G2 R3 V4 A7 Q8 R9 K10 G11 S14 V15 K17 S18 H19 T20 H21 H22 R23 G25 T31 F34 R37 G39 Y40 H50 P52 R54 R64 F67 R68 Y69 K70 H71 T84 G85 F87 Y89 A94 T95 H118 K119 V125 F126 A127 R128 C129 S130 G131 D132 L150 P151 S152 K156 G172 G173 R174 T175 K177 M179 L180 K181 A182 G183 H187 K188 K192 R193 N194 W196 P197 K198 V199 R200 G201 V202 M204 N205 P206 V207 E208 H211 G213 G214 N215 H216 Q217 H218 G220 H221 A222 S223 T224 V225 R226 R227 D228 P230 P231 G232 Q233 K234 V235 G236 L237 I238 A239 A240 R241 R242 T243 G244 R245 L246
Binding residue
(residue number reindexed from 1)
G1 R2 V3 A6 Q7 R8 K9 G10 S13 V14 K16 S17 H18 T19 H20 H21 R22 G24 T30 F33 R36 G38 Y39 H49 P51 R53 R63 F66 R67 Y68 K69 H70 T83 G84 F86 Y88 A93 T94 H117 K118 V124 F125 A126 R127 C128 S129 G130 D131 L149 P150 S151 K155 G171 G172 R173 T174 K176 M178 L179 K180 A181 G182 H186 K187 K191 R192 N193 W195 P196 K197 V198 R199 G200 V201 M203 N204 P205 V206 E207 H210 G212 G213 N214 H215 Q216 H217 G219 H220 A221 S222 T223 V224 R225 R226 D227 P229 P230 G231 Q232 K233 V234 G235 L236 I237 A238 A239 R240 R241 T242 G243 R244 L245
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7qiw, PDBe:7qiw, PDBj:7qiw
PDBsum7qiw
PubMed35643637
UniProtP29766|RL8_SOLLC Large ribosomal subunit protein uL2 (Gene Name=RPL8)

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