Structure of PDB 7qbv Chain D Binding Site BS01

Receptor Information
>7qbv Chain D (length=407) Species: 2214 (Methanosarcina acetivorans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEVVVDVGGNPGVDCKGFCKYCYFKKVKDIQPLGCKYCLPFKKGCDYCTR
SVKESYSGFKSLQMVLEETANKLYFVKKFTVSGGGDLSCYPELKSLITFL
SQFNTPIHLGYTSGKGFSKPDDALFYIDNGVTEVSFTVFATDPALRAEYM
KDPEPEASIQVLRDFCTHCEVYGAIVLLPGINDGEVLEKTLCDLENMGAK
GAILMRFANFQENGLILNNSPIIPGITPHTVSEFTEIVRSSAEKHPSIRI
TGTPLEDPLIGSPFAIRNVPEALLKLPRVSKKATIITGQVAASRLTEIFE
ALGGTVNVIPVKKDIGCLITIDDFKALDLSEVTETVFIPGRAFVHDMEIK
EALRRDGVDRIVRRGPERLSVDGEMSIGMTREEVLELEVENFTELIGQIN
SLGLPLE
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7qbv Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qbv Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase.
Resolution2.701 Å
Binding residue
(original residue number in PDB)		P11 G12 C15 F18 C19 C22 Y115 S117 K119
Binding residue
(residue number reindexed from 1)		P11 G12 C15 F18 C19 C22 Y111 S113 K115
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.379: [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0035244 protein-arginine C-methyltransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0032259 methylation
GO:0043687 post-translational protein modification

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7qbv, PDBe:7qbv, PDBj:7qbv
PDBsum7qbv
PubMed35110733
UniProtQ8THG6|MCRAM_METAC [Methyl coenzyme M reductase]-L-arginine C-5-methyltransferase (Gene Name=MA_4551)

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