Structure of PDB 7q3e Chain D Binding Site BS01

Receptor Information
>7q3e Chain D (length=226) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVPDWHETVEGKEYLACILRKNRRREFGLLERPVLPPSVVIDTASYKIFV
SGKSGVGKTALVAKLAGLEVPIVHHETTGIQTTVVFWPAKLKASDCVVMF
RFEFWDCGESALKKFDHMLPACKENADAFLFLFSFTDRASFEDLPGQLTR
VAGEAPGLVKIVIGSKFDQYMHTDVPARDLTAFRQAWELPLFRVKSVPLD
GRAGLADTAHVLNGLAEQLWHQDQVA
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain7q3e Chain D Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7q3e Structure of the ciliogenesis-associated CPLANE complex.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		S64 G67 K68 T69 I82 H84 T87 K176 D178 S206
Binding residue
(residue number reindexed from 1)		S54 G57 K58 T59 I72 H74 T77 K166 D168 S196
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0003274 endocardial cushion fusion
GO:0006887 exocytosis
GO:0007224 smoothened signaling pathway
GO:0008104 protein localization
GO:0008589 regulation of smoothened signaling pathway
GO:0015031 protein transport
GO:0016485 protein processing
GO:0017157 regulation of exocytosis
GO:0030030 cell projection organization
GO:0031338 regulation of vesicle fusion
GO:0035082 axoneme assembly
GO:0060173 limb development
GO:0060271 cilium assembly
GO:1904888 cranial skeletal system development
Cellular Component
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0035869 ciliary transition zone
GO:0036064 ciliary basal body
GO:0097546 ciliary base

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7q3e, PDBe:7q3e, PDBj:7q3e
PDBsum7q3e
PubMed35427153
UniProtA2A825|CPLN2_MOUSE Ciliogenesis and planar polarity effector 2 (Gene Name=Cplane2)

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