Structure of PDB 7phw Chain D Binding Site BS01

Receptor Information
>7phw Chain D (length=312) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RHVFIRTELSFIKNNVPCIRDMFFIYKRELYNICLDDLETHIYVQKKVKD
SWITLNDLFKETDLTGRPHIFAYVDVEEIIILLCEDEEFSNRKKDMTCHR
FYSNDGKEYNNAEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPD
DILCMASHDKGETWGTKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVG
DNIVKNVNFIECTHEKDLEFVCSNRDFLKDNKVLQDVSTLNDEYIVSYGN
DNNFAECYIFFNNENSILIKPEKYGGCYGGTFVKIDENRALFIYSSSQGI
YNIHTIYYANYE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7phw Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7phw Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Resolution2.793 Å
Binding residue
(original residue number in PDB)		E120 E122
Binding residue
(residue number reindexed from 1)		E85 E87
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0005515 protein binding
Biological Process
GO:0044409 symbiont entry into host
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0020002 host cell plasma membrane
GO:0020009 microneme
GO:0031410 cytoplasmic vesicle
GO:0032991 protein-containing complex
GO:0034494 microneme lumen
GO:0043655 host extracellular space
GO:0045177 apical part of cell

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7phw, PDBe:7phw, PDBj:7phw
PDBsum7phw
PubMed35177602
UniProtQ8IFM8|CYRPA_PLAF7 Cysteine-rich protective antigen (Gene Name=CyRPA)

[Back to BioLiP]