Structure of PDB 7oyd Chain D Binding Site BS01

Receptor Information
>7oyd Chain D (length=289) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMI
VRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
LLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLAR
TTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQ
NVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPV
YEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQ
Ligand information
>7oyd Chain 5 (length=3358) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacccggcgccggggggcccaaguccuucugau
cgaggccgcccguggacggugugaggccgguagcggcccccggcgcgccg
ggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgg
gugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaac
aaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagag
ggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccg
gaggaucaacccggcggcggccggccgugccggggggcggaucuggaccg
ccccccggccggcgaccggccgccgccgggcgcauuuccaccgggcggug
cgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggc
ccggccggguguuacagcccgcccccggcagcagcgacucgccgaauccc
ggggccgagggagcgagacccgugccgccgcgcucuccccccuggggggg
ccgggccaccccucccacggcgcgaccgcggggcggacuguccagugcgc
cccgggcgggucgcgccgucgggcccggggggccacgcgcgagcgcacgg
ggucggcggcgaugucggcuacccacccgacccgucuugaaacacggacc
aaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcg
caaugaaggugaaggccgggccgaggugggaucccgaggccucuccaguc
cgccgagggcgcaccaccggcccgucucgcccgccgcgccggggaggugg
agcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggc
agggcgaagccagaggaaacucugguggagguccguagcgguccugacgu
gcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaacca
ucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuc
gcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuu
uaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugc
gagugccuagugggccacuuuugguaagcagaacuggcgcugcgggauga
accgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaga
aaagguguugguugauauagacagcaggaugguggccauggaagucggaa
uccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaa
aauggauggcgcuggagcgucgggcccauacccggccgucgcuggcaguc
ggcagagcgagaaagagagugggcggacgcuacgccgcgacgaguaggag
ggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccg
ccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuu
gaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggu
cagucgguccugagagaugggcgagcgccguuccgaagggacgcucagcc
gaucgaaagggagucggguucagauccccgaauccggagcggagaugggc
guccagugcgguaacgcgaccgaucccggagaagccggcgggagccccgg
ggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucg
ccccgagagaggggcccgugccuuggaaagcgucgcggcguccggugagc
ucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgg
gccguacccauauccgcagcaggucuccaaggugaacagccucuggcaug
uuggaacaauguagguaagggaagucggcaagccggauccguaacuucgg
gauaaggauuggcucuaagggccgacuuagaacuggugcggaccagggga
auccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcgggugu
ugacgcgaugugauuucugcccagugcucugagucaaagugaagaaauuc
aaugaagcgcggguaaacggcgggaguaaugacucucuuaagguagccaa
augccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucc
cacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuu
ggcggaaucagcggggaaagaagacccuguugagcuugacucuagucugg
cacggugaauucacugacccggugaggcgggggggccucgcuucuggcgc
caagcgcccgcgggcgcgacccgcuccggggacagugccagguggggagu
uugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcg
agcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgc
uugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacg
auccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuacca
cagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuu
ugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaa
gcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccg
ucgugagacagguuaguuuuacccuacugaugauguguuguugccauggu
aauccugcucaguacgagaggaaccgcagguucagacauuugguguaugu
gcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugac
ugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggag
ccucgguuggccucggauagccggccggugcggagagcccuucgucccgg
gaaacgggccggaaaggggccgcgcccgucacgcaccgcacguucguggg
gaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuu
cguacguagcagagcagcugcgaucuauugaaagucagcccucgacacaa
ggguuugu
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.>>>>...((......<<<.....))>>>...>.>>>>>>>...>.>>>>
>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....((
(((..<<<<<<)))))..]]].............................
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........................<<<<<<<<..<<<.<<...<<<<<<<
<.<<<....<<<<<<<<<<<<<<<<<<.<<<<<<<<<<<<.<<..>>>>>
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.<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<..<<<......<<
<<<..>>>>>.......>>>..>>..>>>.........>>>>>>...>>>
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>>>..>..>>>>>>>>>>>.>>>...>>>>>.>.......>>>>>>....
.>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<
<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>.
..<<....>>...<<<<.>>>>..<<<<<...<<<..<<.....(((.[[
..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>
.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.
.<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<...
.....>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>
>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..
<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>
>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>
>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<.....
.>>>...<<<<<<<...<<<(((.......<<<<<......<........
..<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>..
..>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...
.......))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....
................]].)))...........>>>>>>>>>....>>>>
>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>
>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>
>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>..
..((<<<<<<...<<....<<<....>>>..........<<...>>....
..>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<.
.>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<
<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<....
.>>>.....>>>>>>>>..>>>>>.....<<<<<..>>>>>>>>>...>>
>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>
.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>...
.<<<<.....<<<<<<<.<<.........<.....<<<<<..........
.....>>>>><<.<<<<<<......>>>>>>.>>............<<<<
<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>..
....>>>>>>>...<<..<<<..<<<<<<...<<.....<<<<....>>>
>.....>>..>>>>..>>>>><<<<<<....>>>>>>........<....
.......<<<<<.......>>>>>.....>.....>>....>>.>>>>>>
>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>
>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<
<<<.<<<<..>>>>...<<<<<.....<<<<..<<..>>...........
...<<<<<<..>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>
...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<
<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>
>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]...
...((((((..(((..>>>>>>.)))))))))..........]]]]..}}
]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...
>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...
>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<
<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<.
.<.<<<<<.................>>>>>.><<<<....<<<<....<<
.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<
<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<<..
<<<<....<<<........<<<<..>>>>.......>>>...<<<..<<<
<......<<<.......>>>....>>>>..>>>..............>>>
>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<
.....<<<<....<<<..>>>...>>>>....>>....>>>>.>>>.>>.
.>>>>>..
Receptor-Ligand Complex Structure
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PDB7oyd A molecular network of conserved factors keeps ribosomes dormant in the egg.
Resolution2.3 Å
Binding residue
(original residue number in PDB)
F3 K5 K8 K10 K14 R15 Y16 Q17 R23 T28 D29 Y31 R35 L36 K43 Y44 K48 Y49 F113 M115 G140 A141 F142 Y145 L150 R152 T153 F160 P174 H175 S176 R179 R268 S272 A274 Q275 D278 R279 Q282 K283 S286 R289 A290
Binding residue
(residue number reindexed from 1)
F1 K3 K6 K8 K12 R13 Y14 Q15 R21 T26 D27 Y29 R33 L34 K41 Y42 K46 Y47 F111 M113 G138 A139 F140 Y143 L148 R150 T151 F158 P172 H173 S174 R177 R266 S270 A272 Q273 D276 R277 Q280 K281 S284 R287 A288
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7oyd, PDBe:7oyd, PDBj:7oyd
PDBsum7oyd
PubMed36653451
UniProtP19949|RL5_RABIT Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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