Structure of PDB 7oqy Chain D Binding Site BS01

Receptor Information
>7oqy Chain D (length=258) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPISLIERNGLRLRLVLENYPLEFVNSIRRASILYVPVMAVDEVYFIENN
SPLYDEILAHRLALVPFVSDEALEHYRPPEECCDGCYNRVYLDVEAKDQP
LMIYSRDLKSEDQMITPVSGAIPIVLLGSKQKISLEARLRLGYGKEHIKY
SPVSVSIVRYYPKVTVLGNCEKAVEVCPEGVFAMENNKLVVKNELSCILC
EECLKYCAGSVSIESVENKFILEIESVGSLKPERILIEASKSLLRKLSEL
KSKLEAGK
Ligand information
Ligand IDF3S
InChIInChI=1S/3Fe.4S
InChIKeyFCXHZBQOKRZXKS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385S1[Fe]S[Fe]2S[Fe]1S2
OpenEye OEToolkits 2.0.7S1[Fe]2S[Fe]3[S]2[Fe]1S3
FormulaFe3 S4
NameFE3-S4 CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7oqy Chain D Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7oqy Structural basis of RNA polymerase inhibition by viral and host factors.
Resolution2.61 Å
Binding residue
(original residue number in PDB)		C183 C203 I204 L205 C206 E207 E208 C209 I219
Binding residue
(residue number reindexed from 1)		C177 C197 I198 L199 C200 E201 E202 C203 I213
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
GO:0051536 iron-sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oqy, PDBe:7oqy, PDBj:7oqy
PDBsum7oqy
PubMed34535646
UniProtP39471|RPO3_SULAC DNA-directed RNA polymerase subunit Rpo3 (Gene Name=rpo3)

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