Structure of PDB 7oi7 Chain D Binding Site BS01

Receptor Information
>7oi7 Chain D (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANFVSWKSRTKYTITPVKMRKSGGRDHTGRIRVHGIGGGHKQRYRMIDFL
RFRPEETKSGPFEEKVIQVRYDPCRSADIALVAGGSRKRWIIATENMQAG
DTILNSNHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAA
GTCGVLLRKVNGTAIIQLPSKRQMQVLETCVATVGRVSNVDHNKRVIGKA
GRNRWLGKRPNSLPPMKSYV
Ligand information
>7oi7 Chain A (length=1054) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucaguacaugcuaagacuucaccagucaaagcgaaccuca
auugauccaauaacuugaccaacggaacaaguuacccuaggguaucuacu
uuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaa
gcgccuucuaaaugauaucaucucaacuuaauacccacacccaagaacag
gguu
<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>......>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>..
.......<<<....>>>............>>>>..>>>>>>>..>>>.>>
..<<<.<<<.................>>>.>>><<<<<...<<<....>>
>.>>>>>.<<<.<............>.>>>........<<<<.......>
>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oi7 A distinct assembly pathway of the human 39S late pre-mitoribosome.
Resolution3.5 Å
Binding residue
(original residue number in PDB)
A61 W66 K67 R69 K71 I74 T75 P76 K78 K81 S82 G84 R85 H87 T88 G89 R90 I91 R92 V93 H100 K101 R103 Y104 R105 F109 R130 Y131 P133 R135 L141 W150 R202 Q205 Y206 I207 R208 A209 A210 G211 L228 P229 S230 R232 H252 N253 I257 G258 A260 G261 R262 N263 R264 W265 R269 P270 N271 S272 Y295
Binding residue
(residue number reindexed from 1)
A1 W6 K7 R9 K11 I14 T15 P16 K18 K21 S22 G24 R25 H27 T28 G29 R30 I31 R32 V33 H40 K41 R43 Y44 R45 F49 R70 Y71 P73 R75 L81 W90 R142 Q145 Y146 I147 R148 A149 A150 G151 L168 P169 S170 R172 H192 N193 I197 G198 A200 G201 R202 N203 R204 W205 R209 P210 N211 S212 Y219
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7oi7, PDBe:7oi7, PDBj:7oi7
PDBsum7oi7
PubMed34315873
UniProtQ5T653|RM02_HUMAN Large ribosomal subunit protein uL2m (Gene Name=MRPL2)

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