Structure of PDB 7ohx Chain D Binding Site BS01

Receptor Information
>7ohx Chain D (length=424) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKFEELKLSQPTLKAIEKMGFTTMTSVQARTIPPLLAGRDVLGAAKTGSG
KTLAFLIPAIELLHSLKFKPRNGTGIIVITPTRELALQIFGVARELMEFH
SQTFGIVIGGANRRQEAEKLMKGVNMLIATPGRLLDHLQNTKGFVFKNLK
ALIIDEADRILEIGFEDEMRQIIKILPNEDRQSMLFSATQTTKVEDLARI
SLRPGPLFINVLEQGYVVCDSDKRFLLLFSFLKRNQKKKIIVFLSSCNSV
KYYAELLNYPVLELHGKQKQQKRTNTFFEFCNAERGILICTDVAARGLDI
PAVDWIIQFDPPDDPRDYIHRVGRTARGTKGKGKSLMFLTPNELGFLRYL
KASKVPLNEYQSQLEKLIKSNYYLHQTAKDGYRSYLQAYASHSLKTVYQI
DKLDLAKVAKSYGFPVPPKVNITI
Ligand information
>7ohx Chain 1 (length=1561) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugaccucaaaucagguaggaguacccgcugaauaucaauaagcggag
gaaaagaaaccaaccgggauugccuuaguaacgcgagugaagcggcaaaa
gcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggaga
gggcacuuuggggccguuccuugucuauguuccuuggaacaggacgucau
agagggugagaaucccguguggcgaggagugcgguucuuuguaaagugcc
uucgaagagucgaguuguuuggaugcagcucuaagugggugguuccaucu
aaagcuaaauauuggcgagagaccgauagcgaacaguacagugauggaaa
gaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaa
aggaagggcauuugaucagacaugguguuuugugcccucugcuccuugug
gguaggggaucucgcauuucacugggccagcaucaguuuugguggcagga
uaaauccauaggaauguagcuugccgguaaguauuauagccugugggaau
acugccagcugggacugaggacugcgacguaagucaaggaugcuggcaua
augguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucu
augcgaguguuuggguguaaaacccauacgcguaauugaacguagguugg
ggccucgcaagaggugcacaaucgaccgauccuggauggauuugguaaga
gcauagcuguugggacccgaaagauggugaaaaccaucuaguacugguuc
cugccgaaguuucccucaggauagcagaagcucguaucaguuuuauguaa
gaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugc
gggaugaaccgaacguagaguuaaggugccggaauacacgcucaagaaca
aaauaguucaucuagaccggguggccauggaagucggaauccgcuaagga
guguguaacaaccggaugaacuagcccugggcgcucaagcguguuaccua
uacucuaccgucaggguugauaugaugcccugacgaguaggcaggcgugg
aggucagugacgaagccuagaccguaaggucgggucgaacggccucuagu
gcagaucuuggugguaguagcagcgaaaccacaccaaggggcuuggcuac
cgaagcagaaguaauguuaccgcaauaguaauugaacuuaguacgagagg
aacaguucauucggauaauugguuuuugcggcugucucaggcagccgcga
agcuaccauccgcuggauuauggcugaacccucuaagucagauccaugcu
agaagcggugaugcuccacacagauggauacgaauaaggcguccuugugg
cgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccu
ugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauac
gacuuagauguacaacgggguauuguaagcgcugagauuaagccuuuguu
gucugauuugu
..........................<<<<<<...........>>>>>.>
.........<<....>>..<<<<<......<<....>>.....>>>>>..
<<<...........<<.<<<<<<...>>>>>>.>>.............<<
<<<<<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((...
...<<<.....))>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>
>>>........<<<<<<<......>>>>>>>.....<<<<<<..>>>>>>
..>>>.................................<<....>>....
...........<<<......>>>...........................
......<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....>
>>>>>>>>.....>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<..
...<<<<<<<<<......<<<<<....>>>>>.......>>>>>>>.>.>
.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>...
.>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<
<<<<..<<<...<<<<.....>>>>...>>>.............<<<<<.
.<<<<<....>>>>>...>>>>>.<<<...<<.....>>....>>>....
>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>.....>.>>..<
<<<<<......<<......>>..<<<<<<<<<....<<<.<<<<<..>>>
.>>>>>..>>>>>>>.>>..<<<<.<.<<<.....>>>>..>>>>....<
<<......>>>...<<<<<<<..<<<<(((.....<<<<<<....<....
...<<<<<<<<......<<.....<<.........>>.............
..<<......>>>>.>>>>>>>>......))).>....>>>>>>.>>>>.
.>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<
<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..
>.....>>>>>><<.....<<.>>....>>...<<<<<...>>>>>.<<<
..........>>>..<<<<<<<<..<<<<.<.<<<<<<............
...>>>>>>.><<<<<...<<<<....<<<<<...........>>>>>..
.>>>>..>>>>>.<<<<...<<<<<..........>>>>>..>>>>.>>>
>...>>>>>>>>.<<<<<<......<<..........<<<<<<.....>>
>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>.
.>.>>>>>.>>>>>>............>>>>>>.<<<<<<<<........
.....>.....<<<<<<<<<.<<<....<..>...>>>....>>>.>>>>
>>.>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ohx Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N153 R155 Q156 E159 Q441 R448
Binding residue
(residue number reindexed from 1)		N112 R114 Q115 E118 Q376 R383
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008186 ATP-dependent activity, acting on RNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:1990417 snoRNA release from pre-rRNA
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0030687 preribosome, large subunit precursor
GO:0032040 small-subunit processome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ohx, PDBe:7ohx, PDBj:7ohx
PDBsum7ohx
PubMed34813592
UniProtQ03532|HAS1_YEAST ATP-dependent RNA helicase HAS1 (Gene Name=HAS1)

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