Structure of PDB 7lo0 Chain D Binding Site BS01

Receptor Information

>7lo0 Chain D (length=151) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEE
YDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYR
GQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHIN
W

Ligand information

>7lo0 Chain L (length=16) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

LDPRRQELLEARFTGV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7lo0 Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Resolution	2.71 Å
Binding residue (original residue number in PDB)	A48 E49 D54 D88 V92 V94 R108 G110 Y112 F149
Binding residue (residue number reindexed from 1)	A46 E47 D52 D86 V90 V92 R106 G108 Y110 F147

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006325	chromatin organization

	Cellular Component
GO:0005634	nucleus

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Biological Process

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Cellular Component

External links

PDB	RCSB:7lo0, PDBe:7lo0, PDBj:7lo0
PDBsum	7lo0
PubMed	35136069
UniProt	Q9Y294\|ASF1A_HUMAN Histone chaperone ASF1A (Gene Name=ASF1A)

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